Seattle Seahawks 31-33 Washington Commanders

Marcus Mariota threw three touchdown passes, and Kain Medrano returned an interception 50 yards for a touchdown to help the Washington Commanders (1-2) hand Seattle (2-1) their first loss since last November. The Seahawks had won 12 straight, including their postseason run to last season’s Super Bowl title, but Mariota was solid in place of the injured Jayden Daniels, and three crucial turnovers enabled Washington to win their home opener. Jaxon Smith-Njigba caught 10 passes for 128 yards and two touchdowns for the Seahawks, and he even completed a short throw on a trick play in the final quarter.

Cincinnati Bengals 27–30 Pittsburgh Steelers

Aaron Rodgers passed for 292 yards and three touchdowns to outduel Joe Burrow as the Pittsburgh Steelers beat the Cincinnati Bengals. Pittsburgh bounced back from a miserable performance in a loss to New England to blunt some of Cincinnati’s early momentum. Rodgers completed 19 of 34 passes, including a 47-yard catch-and-run to 6ft 7in 265lb tight end Darnell Washington that helped set up Chris Boswell’s go-ahead, 33-yard field goal with 2:18 remaining. Cincinnati had a chance late, but Burrow fumbled after being sacked by Derrick Harmon. Rookie Sebastian Joseph-Day fell on the ball. Both teams are 2-1.

New England Patriots 6–35 Jacksonville Jaguars

Trevor Lawrence threw three touchdown passes, leading the Jacksonville Jaguars to a statement victory over the visiting New England Patriots. Lawrence connected ⁠with Josh Cameron, Jakobi Meyers and Parker Washington for scores, completing 19 of 29 passes for 182 yards with an interception. Meyers had seven catches for 64 ⁠yards, while Bhayshul Tuten ⁠rushed for 73 yards ​and a score for Jacksonville (2-1), who won their sixth straight regular-season home game. New England quarterback Drake Maye continued to struggle with turnovers. He paired two interceptions ⁠with one lost fumble to give him seven turnovers in three games, already approaching the 11 he had in 17 regular-season games last season. Maye was 14-of-25 passing for 199 yards, ⁠while Mack Hollins caught six passes for 87 yards for the Patriots (1-2).

Los Angeles Chargers 16-24 Buffalo Bills

Josh Allen scored two touchdowns rushing and the Buffalo Bills overcame a five-turnover outing to pull out a victory over the 0-3 Los Angeles Chargers. Allen’s second score, a one-yard plunge with 7:35 left, gave Buffalo their first lead. The Bills then sealed the win on James Cook’s three-yard run four minutes later, after Buffalo’s defense forced Justin Herbert’s incompletion on fourth down at the Chargers 45. Buffalo improved to 3-0 despite Allen throwing two interceptions and losing a fumble. Cook and tight end Dalton Kincaid also lost fumbles.

Kansas City Chiefs 24–10 Miami Dolphins

Kenneth Walker III had a touchdown catch and rushed for a score, Patrick Mahomes threw for 246 yards and two TDs, and the Kansas City Chiefs (3-0) beat the Miami Dolphins. The Chiefs entered averaging more than 450 yards and 32 points but struggled to pull away from the 0-3 Dolphins. Miami were missing arguably their best player for much of the game after Pro Bowler De’Von Achane left with a knee injury on the opening drive. Mahomes completed 20 of 24 passes with a five-yard touchdown to Walker but needed an 11-yard TD pass to Travis Kelce to put the game out of reach.

New York Jets 24–31 Detroit Lions

Jahmyr Gibbs had a go-ahead 11-yard reception with 2:25 left for his third touchdown of the game and the Detroit Lions (2-1) held on to beat the New York Jets (1-2). The dynamic running back had 20 carries for 99 yards with 17- and 1-yard touchdown runs along with seven receptions for 65 yards and a score. With a chance to tie the game or perhaps go for the win, the Jets were on the Detroit 28. But Smith fumbled after blitzing safety Chuck Clark sacked him, with Garrett Wilson on the sideline after he was hit hard on the previous play.

Carolina Panthers 18–21 Cleveland Browns

Deshaun Watson threw two touchdown passes to Harold Fannin Jr, including a 14-yard strike with 1:48 remaining, and the Cleveland Browns (2-1) rallied for victory over the Carolina Panthers (1-2). The Panthers went in front 18-13 with 4:25 remaining when John Metchie III hauled in an eight-yard touchdown pass from Bryce Young. But the Browns went 65 yards in eight plays for their second straight comeback win. Watson was 10 of 21 for 67 yards during the first three quarters but was 6 of 9 for 77 yards over the final 15 minutes. He was cheered by fans after he returned to the field following a hard hit.

Tennessee Titans 7-12 New York Giants

Relying on running the ball in their first game without quarterback Jaxson Dart, the New York Giants beat the Tennessee Titans but lost their most important defensive player, Brian Burns, to a knee injury. Burns went down grabbing at his right knee midway through the fourth quarter and had to be helped off the field. If it is significant like Dart’s injury, which has him out for at least the remainder of the regular season, it is another blow to the Giants (2-1) after John Harbaugh’s tenure as coach got off to a promising start. The Titans fell to 0-3.

Houston Texans 17–19 Indianapolis Colts

Spencer Shrader kicked four field goals, including a 53-yarder with 16 seconds remaining, to lead the Indianapolis Colts to victory. Shrader matched his career best of 58 yards to help the Colts (1-2) snap ⁠a five-game losing streak ⁠against their ​AFC South rivals. Daniel Jones was 24-of-36 passing for 235 yards, one touchdown, one interception and two lost fumbles for the Colts. Keenan ⁠Allen caught a touchdown pass and Indianapolis halted a nine-game overall skid dating back to last season. Will Anderson Jr recorded 2.5 sacks, forced one fumble ⁠and recovered another for the Texans (0-3), who didn’t commit a turnover while forcing three Indianapolis miscues.